I am a researcher studying diseases. You have no idea how many mice get killed without generating any data. There’s a rule in place whenever you want to work with animals that you need to plan ahead and only use as few animals as you need to get the data that you’re looking for. But things in research basically never happen according to plan. It could be due to a variety of factors: unexpected failures, overlooked factors, technical errors, or just simple negligence when performing an experiment. A lot of data and samples obtained from killed mice are discarded for one or more of the above reasons.
I get that mouse experiments are important to prove that our findings can translate to actual living animals, but I personally will not touch a mouse because, frankly, the “useful data per mouse” ratio is way too low for me to justify using mice.
While you didn’t get the data you were looking for, at least in many of those cases you mentioned you did identify a flaw or failure and learned how to design an experiment that does.
I wouldn’t consider those mice as dieing without teaching you something. It might be a failed experiment, but you learned something.
I may be misreading them but it sounds like they’re describing avoidable problems.
Like when we were doing “oral” vaccinations with a oral gavage needle (ball tip) and going through the mouth and dosing in the stomach. We had a vial of 70% alcohol to clean the tip. Accidentally drew the alcohol up instead of the vaccine. By the time we finished the cage (6 mice, I think) the first one fell over.
How online ads actually work.
Very simplified TLDR: you visit a news site. They load an ad network and tell it “put ads here, here and here”.
The ad network now tells 300 companies (seriously, look at the details of some cookie consent dialogs) that you visited that news site so they can bid for the right to shove an ad in your face.
One of them goes “I know this guy, they’re an easy mark for scams according to my tracking, I’ll pay you 0.3 cents to shove this ad in their face”. Someone else yells “I know this guy, he looked at toasters last week, I want to pay 0.2 cents to show him toaster ads just in case he hasn’t bought one yet.”
The others bid less, so that scam ad gets shoved in your face.
That’s extremely simplified of course. https://en.wikipedia.org/wiki/Real-time_bidding has a bit more of an explanation.
And how you’re tracked online. I’ve worked on Google ads accounts every day for a decade and I don’t see you,the user, and your data.
I just click “female, 50+, likes home decor, uses a phone” and then a little business I work with bids 10% extra on you because they think you might be interested in their new autumn wreaths they’re super proud of, and Google think you fit that box I ticked.
And that’s advanced marketing for most businesses. Most businesses won’t even get into the audience side of things and they’ll stick to keywords: they’ll show you an ad because you searched for “autumn home decor” and that’s all.
Google take advantage of most advertisers by saying "let us be in charge of your keywords, and how much money you spend, our AI is smarter than you and you don’t have time!"And most businesses just use the automatic stuff because they don’t understand it, and it’s true, they don’t have time… so then Google takes your “autumn wreath” keyword and shows your ads to someone looking for “Christmas trees”, because they’re both seasons and they’re both plant related, right?
And then the small business gets charged $1 by Google to show their autumnal page to someone who wasn’t interested and left right away.
My job is to help these businesses actually make an advertising account that doesn’t fall for all these little bear traps that Google sets all over their ads interface. They weren’t there 7 years ago, but things have been getting worse and worse. Including third party sales companies like regalix, hired by Google to constantly call you and telling you to trust the automation and spend more.
It’s fascinating that the enshittification is taking place on both ends of Google. I would have thought that the slow bastardization of search was for the benefit of advertizers but it’s bad for everyone except Google.
That was always part of the enshittification formula. The final stage after exploiting users is to exploit business customers to the breaking point.
Software Engineering. Most software is basically just houses of cards, developed quickly and not maintained properly (to save money ofc). We will see some serious software collapses within our lifetime.
Package management is impossible. When a big enough package pushes an update the house of cards eill fall. This causes project packages with greatly outdated versions to exist in production because there is no budget to diagnose and replace packages that are no longer available when a dependency requires a change.
Examples: adminJs or admin bro… one of them. Switched the package used to render rich text fields.
React-scripts or is it create react app, I don’t recall. Back end packages no long work as is on the front end. Or something like that? On huge projects, who’s got the budget to address this to get the project up to date?
This has to be a world wide thing. There is way to many moving targets for every company to have all packages up to date.
It’s only a matter of time before an exploit of some sort is found and who knows what happens from there.
Y2038 is my “retirement plan”.
(Y2K, i.e. the “year 2000 problem”, affected two digit date formats. Nothing bad happened, but consensus nowadays is that that wasn’t because the issue was overblown, it’s because the issue was recognized and seriously addressed. Lots of already retired or soon retiring programmers came back to fix stuff in ancient software and made bank. In 2038, another very common date format will break. I’d say it’s much more common than 2 digit dates, but 2 digit dates may have been more common in 1985. It’s going to require a massive remediation effort and I hope AI-assisted static analysis will be viable enough to help us by then.)
Windows, Linux, FreeBSD, OpenBSD, NetBSD, and OSX have all already switched to 64 bit time.
Tell that to the custom binary serialization formats that all the applications are using.
Edit: and the long-calcified protocols that embed it.
So they have a year 202020 bug then
I get the joke, but for those seriously wondering:
The epoch is Jan 1, 1970. Time uses a signed integer, so you can express up to 2^31 seconds with 32 bits or 2^63 with 64 bits.
A normal year has exactly 31536000 seconds (even if it is a leap second year, as those are ignored for Unix time). 97 out of 400 years are leap years, adding an average of 0.2425 days or 20952 seconds per year, for an average of 31556952 seconds.
That gives slightly over 68 years for 32 bit time, putting us at 1970+68 = 2038. For 64 bit time, it’s 292,277,024,627 years. However, some 64 bit time formats use milliseconds, microseconds, 100 nanosecond units, or nanoseconds, giving us “only” about 292 million years, 292,277 years, 29,228 years, or 292 years. Assuming they use the same epoch, nano-time 64 bit time values will become a problem some time in 2262. Even if they use 1900, an end date in 2192 makes them a bad retirement plan for anyone currently alive.
Most importantly though, these representations are reasonably rare, so I’d expect this to be a much smaller issue, even if we haven’t managed to replace ourselves by AI by then.
an end date in 2192 makes them a bad retirement plan for anyone currently alive.
I can’t wait to retire when I’m 208 years old.
Omg we are in same epoch as the butlarian crusade.
Butlarian crusade
Butlerian Jihad, my dude. Hate to correct you, but the spice must flow.
Im just glad you got that reference
If you’re going to correct people about Dune quotes, at least use one from the book! “The spice must flow” doesn’t appear in any of them, it’s a Lynch addition.
How many UNIX machines in production are still running on machines with 32-bit words, or using a 32-bit time_t?
My dad is a tech in the telecommunications industry. We basically didn’t see him for all of 1999. The fact that nothing happened is because of people working their assess off.
My dad had to stay in his office with a satellite phone over new years in case shit hit the fan.
My dad still believes the entire Y2K problem was a scam. How do I convince him?
Well my dad does too and he worked his ass off to prevent it. Baby boomers are just stupid as shit, there’s not really much you can do.
For those in the US: no medical office dealing with insurance has a clue what they’re doing. Why can’t you ever “shop around” and get a price for your procedure? Because nobody really knows the price until they submit the claim. It’s basically impossible for a human to keep track of the policies that change daily across dozens of insurance providers along with the hugely complicated calculations needed to get a price. And that’s before they have software try to rearrange your claim to get the most money possible from insurance companies. And good luck figuring any of this out yourself; even if you manage to track down the policy data, it’s written completely in medical insurance jargon and might even leave some room for interpretation.
Basically, even with the insane amount of work medical coders (people who process and interpret medical claims and policies) do to try and stay on top of it all, at the end of the day, you have to just submit the claim to a black hole and hope that it gets accepted. The patient’s cost is whatever it spits out.
Also, dozens of doctors across the US get fired, banned from practice in their state, or have their licenses revoked every month. Some of them are unfortunate, like doctors being forced into retirement due to old age or physical inability to do their job, but many others get in trouble for practicing without a license, sexual harassment/assault, and, of course, prescription drug abuse. This data is all publicly accessible, but being on atrociously designed and maintained government websites, it’s nearly impossible to keep track of who’s in trouble without paying for third party software to do it for you. If you don’t happen to catch it, it’s pretty easy for a medical provider to move a few states over and set up shop like nothing happened.
Edit: Oh yeah, our company was very serious about HIPAA training and treated patient data with extreme caution. Some offices… really didn’t. It got to the point where we’d straight up have to reject ticket requests for having identifying information. Our ticketing system was secure on our end, no telling what was going on outside of it.
As a side note, for the trans people out there, don’t accept that you have to be misgendered on your medical records without a bit of a fuss. There’s special modifiers that specifically override restrictions on sex-based medical procedures when your reported gender doesn’t match their requirements. Unfortunately, whether your provider knows about or uses them is a bit of a toss-up.
On a brighter note, as stupid as it is that every single diagnosis has to be codified specifically for the insurance industry, there are some funny codes in there.
Some favorites:
- Bitten by a dolphin (specifically the first time. There’s different codes for a second bite and any more after)
- The weirdly specific set of codes for various injuries on different watercraft
- Of course, something stuck up your ass
Now there’s a new standard coming into effect, ICD11. The biggest complaint with ICD10 was the overly specific codes they had to keep track of. They did change things so that you didn’t have a completely different code for every single type of, say, dolphin injury, but they did add many more animals.
Cars produce more harmful airbourne pollutants from their brakes than they do from the tailpipe. Copper is being phased out and the ultimate goal is to abandon friction braking entirely in favour of electrical regeneration.
Cars produce more harmful airbourne pollutants from their brakes than they do from the tailpipe.
That’s why you never live nearby a freeway or major highway.
People brake less often on highways?
Have you seen a highway in Los Angeles during rush hour?
…Have you seen almost any other highway in the U.S. ever?
When your favorite band cancels their gig because the lead singer has “come down with the flu”, that’s industry code for “got too wasted, and is currently too busy getting alcohol and possibly drugs out of their system to perform”.
I even worked one show that had to end after 20 minutes because one guy in the band was visibly under the influence, refused to play, talked to his hallucinations, then spent a few minutes talking to the audience about how his foot was evil and wanted to kill him, before the tour manager could drag him off stage. Then he tried to assault several backstage staff for not allowing him to cut off his foot. This was on a tour that promoted alcohol free rockshows btw, so we didn’t provide alcohol to the artists backstage. God knows what he might’ve purchased from our local street dealers lol.
The next day in the papers, the headline says “[the band] cancels first week of reunion tour after flu outbreak” 🙃 Yes, of course
I always wondered why Paul Westerberg caught the flu so much. When I finally got to see him live a few years ago he definitely was coming down with the flu on stage.
[in the US] your insurance dictates your healthcare, not your disease, deformity, symptoms etc. If your insurance pays for an allergy test, you’re getting an allergy test (even if you came in for a broken arm). If insurance pays for custom orthotics, you’re getting custom orthotics (even if you came in for a wart removal). We will bill your insurance thousands of dollars for things you don’t need. We’re forced to do it by the private equity firms that have purchased almost all of American healthcare systems. It’s insane, it’s wasteful. The best part is the person who needs the allergy test or the custom orthotics can’t afford it, so they don’t get the shit we give away to people who don’t need it.
I would gladly kill myself if it meant we got universal healthcare, but private equity firms can’t monitize a martyr so it would be pointless.
Fuck everything about the current US healthcare system. The US can be so much more, can be so much better, if we could somehow just make a single percent stop fucking over the other 99%
Phone systems that give you the prompt, “Press # for more options” etc are called Interactive Voice Response (IVR) systems. If you encounter an IVR that asks for credit card info, social security number, etc, don’t enter it in! If you stay silent, you will usually be routed to an agent, though that varies on whichever system you are calling into.
Even if the system is designed for completely non-nefarious purposes, the IT people who maintain the phone system can analyze call logs to pull electronic keypresses (DTMF) and reconstruct every digit entered to capture your data. Most IT people would never consider abusing this access, but some organizations contract or sub-contract their phone support out to the lowest bidding third parties and might not do a great job of vetting their techs.
Giving this information to a live agent has its own risks, but if you initiated a call to a documented telephone number for the organization you are trying to reach, it is generally a safer option than keying in sensitive digit strings to an IVR. It is much harder for anyone outside of the call center to scan recorded audio for information like this. (Though technology is closing that gap)
Magazines are routinely reprinting articles from the last year every year again, slightly changed. Especially timeless stuff like “Why is tick season so bad this year?” or “This is how you bake the perfect apple pie”.
There are stock news site that churn out “why did $STOCK move in $DIRECTION” filled with bullshit speculation. I bet it was mostly automated even before chatGPT and has gotten much worse now.
Yeah ad sites. Usually they steal blog posts on the topic. Or just copy paste the top SEO spot. Then they highjack the spot and rake in the clicks.
Like 60% of the first page results in an engine are often these types of sites. They add nothing but noise.
I used to work as a contractor for an environmental remediation firm. All the waterways that you joke about not swimming in are actually full of some awful carcinogen. Old industrial plants dumped awful chemicals for years and years. Some of these issues are being slowly addressed, but regulation is always well behind the science. But often, if the liability is significant enough, companies will spend millions of dollars a year to kick the can down the road doing studies and monitoring so that they can avoid what would be hundreds of millions to actually remediate the problem.
Those little widgets that show that something is hot, trending or for a limited time are time based tags and don’t represent any real analysis.
It is virtually impossible to remove yourself from advertiser’s rolls.
Thanks to the new CPRA regulation, you can ask companies to delete everything they know about you. Great!
Except that the way the law is written, that often includes deleting the fact that you asked to have your data removed. So the next time they get your data from a broker, (or the next time a broker gets your data), you’re right back at square one.
In theory, if you managed to send simultaneous requests to every company that’s holding your data, you could wipe the slate clean…until the next time you used a website.
There are so many data sets out there that we are all a part of. And if your data is in just a single one that didn’t get wiped, everyone will end up with it again as a matter of course.
Restaurant manager here, been doing this for a few decades. You do not want to know just how much leeway we get with basic sanitation. Seriously, be very thankful that you have an immune system.
The worms in those strawberries are just some extra protein.
And that is why the Snozzberries taste like Snozzberries!
Not worried about that as much as things that scurry. Barf.
If you want to feel the thrill of hunting some scurrying critters for extra protein, you can get the protein activity package. It’s normally only 17.99 €, but if you also bring a friend, you get a -50% discount.
Wow on sale! Sign me u— waitaminit…
Not a restaurant manger, but I worked for Sbarro’s back in college. The one on campus wasn’t bad, but the one in the mall? We had pizzas sitting under heat lamps for 6 hours or more before they were bought, tossed in the oven for a second, and then handed to the customer. They had to search for gloves because I was the only one who wanted to wear them.
At one point, I needed to put pepperoni on a pizza.i told my manger I couldn’t because the pepperoni was moldy. My manger reached into the bag, pulled a small handful of moldy pepperoni out, threw it out, and declared that rest of the bag perfectly good (without even looking at it).
It’s been 30 years and I still can’t eat at Sbarro.
IMO, for the average, healthy customer, the sanitation requirements are overkill. But not every customer is, so the rules help protect the less healthy customers.
The biggest thing about food, is most of it is pasteurized by the cooking. Raw foods like salads are the ones that need a much higher standard.
I can guarantee you that many of the rules keep even healthy guests with solid immune systems from getting sick or even dying. The FDA Food Code is like 700 pages. There are A LOT of rules. Many seem overkill from a layman’s perspective, but they protect against unlikely but serious consequences. There are a ton of ways that contamination can occur, even after the food has already been cooked.
That you don’t notice is just a good sign that you’re eating at safe places.
Manufacturing here. We dont have a trained QC person looking at our units before sending them to the customer. Its just some guy that checks physical dimensions. We have electronics that comes in for RMA and never gets retested on its way out. Most of our customers dont install the pieces for months so the process control gets muddied by time. Literally everyone in our company knows this. We just got our ISO 9000 cert anyway, because no one really cares about doing things right. We just put untested parts in shit and cross our fingers.
Monocultures in Agribusiness. One ‘public secret’ many outside of the industry might not be aware of is the prevalence of monocultures in crop farming. Vast expanses of land planted with the exact same genetic line of a crop. While this makes farming operations easier and often more profitable in the short term, it’s a ticking time bomb for pests and diseases. One well-adapted pathogen could wipe out an entire crop species in an area (look up citrus greening in Florida), because there’s no genetic diversity to halt its spread. But hey, it keeps the costs down…until there’s no food to eat.
