• casmael@lemm.ee
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    3 months ago

    FROM THE MOMENT I UNDERSTOOD THE WEAKNESS OF MY FLESH IT DISGUSTED ME

  • ArugulaZ@lemmy.zip
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    3 months ago

    Good lord, just let people DIE. Imagine what a rotten place this would be if people with outdated mindsets continued to control the world decades or even centuries after their expiration dates. People were already angry about 80 year old presidential candidates… what happens when they’re 120, or 150?

  • UnderpantsWeevil@lemmy.world
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    3 months ago

    If you want a bit of a deeper dive, Sean Carroll’s Mindscape gets into the science of aging and known workable remedies/treatments.

    The good news is that Billionaires will not be living forever any time soon.

    The bad news is that we’ve got a cellularly defined terminal limit and there’s nothing we can do to simply reset the clock. “Cloned Bodies” for animals are dysfunctional bordering on nightmarish. The human brain’s plasticity isn’t something you can renew with a pill or a potion. Blood Boys don’t work. There aren’t trivially replaceable components in the human body.

    • Echo Dot@feddit.uk
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      3 months ago

      “Cloned Bodies” for animals are dysfunctional bordering on nightmarish.

      That’s nothing to do with the back that clone is impossible and just that cloning is hard. You are acting as if it is an unsolvable problem.

      • UnderpantsWeevil@lemmy.world
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        3 months ago

        clone is impossible

        It’s possible in the sense that you can get near identical genetic replicas of the parent organism.

        But the side effect of this process is in line with historical experiments of inbreeding. Most notably, you get a high instance of progeria, which is the opposite of what you want when aiming for life extension.

        You are acting as if it is an unsolvable problem.

        It is an unsolved problem. Whether it is solveable (either theoretically or practically) is an unanswered question.

        But there’s a real possibility that “anti-aging” is, at its heart, a war against entropy that we can’t win.

        The best we can do may be to archive the information of a subject and pass it on to an inheritor. And we’ve already got a good handle on that, by way of schools and libraries.

        Or maybe not. Maybe there’s a trick to indefinite cellular repair and replacement. It’s just not anywhere on the horizon. If it exists, the closest we’ve come so far is hypothesis. Nothing we’ve tried has successfully undone aging, even at a single cell level.

        • Echo Dot@feddit.uk
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          3 months ago

          But there’s a real possibility that “anti-aging” is, at its heart, a war against entropy that we can’t win.

          You’re going to need to provide some citation on that one because I see no evidence that this is a fundamentally unsolvable problem. It’s not a mathematics issue, it’s a scientific one. As far as I can tell there’s no biological reason that organisms need to age and die, (see lobsters) so it isn’t a war against entropy because entropy isn’t biological aging. They have nothing to do with each other.

          All of the above you would know if you weren’t intent on being a disingenuous twit.

          • UnderpantsWeevil@lemmy.world
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            3 months ago

            You’re going to need to provide some citation on that one

            I linked to the podcast which has citations to the research in the show notes.

            All of the above you would know if you weren’t intent on being a disingenuous twit.

            Take it up with the Second Law of Thermodynamics and Decay Theory of Immediate Memory. You’re trying to turn a human into a Ship of Theseus, but at best all you’re doing is imperfectly copying and replicating the information therein. We run into the same problems with computer memory, and the only real working solution is to make multiple perfect copies at discrete intervals as backup.

            That’s simply not possible at the cellular level at this time. Nor would backup/restore of cellular data be a practical solution, particularly as it regards the human brain, any time in the foreseeable future.

            You’re doomed to die, just like everything else that’s existed to date.

            • Echo Dot@feddit.uk
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              3 months ago

              That’s not how the laws of the thermodynamics works. Biological immortality is perfectly possible and we see it all the time in nature please look it up.

              • UnderpantsWeevil@lemmy.world
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                3 months ago

                Biological immortality is perfectly possible

                Cellular decay is a consequence of entropy. The solution to decay is replication. But replication is imperfect because of errors in the process. You’re still dealing with decay, only this time it is in information.

                we see it all the time in nature

                Point to the immortal organism.

    • RedditRefugee69@lemmynsfw.com
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      3 months ago

      I’d be fine with billionaires getting it first. As much as I’m not a fan of late stage capitalism, I refuse to cut off my nose to spite my face; they got A/C, feather beds, cars, baths, and all sorts of other luxuries long before us plebs got them. Let them beta test the stuff, and by the time the economies of scale pick up enough for it to be affordable to the rest of us, the kinks will be worked out.

      Of course there’s always the possibility of a cartel withholding it from the masses, but that’s what the second amendment and guillotines were invented for.

    • Fedizen@lemmy.world
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      3 months ago

      Its wild this research is even being attempted, its borderline unethical to experiment on otherwise healthy people.

      I fully don’t expect immune system driven aging to be understood until the Thymus better understood. DNA reproduction and telomere related aging will not be addressable until cell to cell signaling is finally mapped, and methylation activation/deactivation can be targeted.

      Most likely some kind of cloned brain tissue can help reduce age-related cognitive decline and some diseases. Imo we’d get far more out of targeting specific diseases than going after aging.

  • bufalo1973@lemmy.ml
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    3 months ago

    This is the correct way IMO. “Uploading” your mind to a computer is making a clone/copy, but the original dies the same.

    • nul9o9@lemmy.world
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      3 months ago

      I agree.

      But here is an interesting thing to think about:

      What is the perceived difference between falling asleep and waking up the next day, vs going to sleep and copying your consciousness to a machine/new body.

        • _NoName_@lemmy.ml
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          3 months ago

          That continuity of function is arbitrary. In reality it provides people comfort in some idea of a soul but there’s nothing suggesting it actually provides anything to the continuity of consciousness.

          Between every loss in time, where you stop forming memories until you wake up again, you have nothing to affirm that your current consciousness is the same as your last waking period’s. The only thing vaguely providing that illusion is your previously-formed memories, which would exist all the same on the digital mind, in theory.

          • Mossy Feathers (She/They)@pawb.social
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            3 months ago

            I don’t think you understand. Your consciousness is just one process amid a myriad of processes that your brain runs. It’s that continuity that matters. You’re correct that I don’t know if my current consciousness is the same as prior consciousnesses, however what matters is that my brain has never shut off, giving me the feeling as though I am the same person; and it is because of that thread that I am the same person (though perhaps with a different consciousness).

            Furthermore, you can’t achieve immortality through digital consciousness if you just copy the whole thing and throw out the original. Again, it’s the continuity. It honestly confuses me why people think that’s a rational idea when the very obvious problem is, “what if something goes wrong and human me wakes up?”

            That’s why you have people, like me, who get frustrated when people start getting philosophical about this shit because they think you can “just make a perfect copy” of a person to achieve immortality.

            Seriously?

            No.

            You just killed yourself and made a copy of yourself. You didn’t achieve shit. Your new self might be happy, but your old self is dead. You’re not suddenly going to wake up as a digital clone. You’re not waking up at all, it’s your clone that’s waking up.

            And hey, if that’s good enough for you, then so be it. Just don’t pretend you’ve achieved immortality; it was your digital clone that did. You’re still going to die.

            It also confuses me that so many people seem to believe that you’re literally brain-dead while you sleep. If you were literally brain-dead then there’d be no way for you to wake up. Sleep seems to be when the brain processes memories too, so if your brain fully shut off, then it wouldn’t be able to processes memories while you’re asleep. Finally, afaik, once the brain shuts off, it can’t turn back on; evolution didn’t plan for a situation in which someone’s been dead long enough for brain activity to cease before their heart starts pumping again. So why does everyone insist that you go brain-dead the moment your head touches the pillow?

            • _NoName_@lemmy.ml
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              3 months ago

              This convo has gone on for centuries at this point. The Brain in the Jar, the teleportation conundrum, Thesius’ ship, it’s all already been covered over and over. people like you still keep crawling out of the woodwork thinking you know better than every philosopher that already waxed over this problem ad nauseum.

              Your ‘continuous self’ is just as worthless as a concept. The idea that your ‘sense of being the same person’ is being held together by being apart of your plumbing just as much of an illusion. It’s worthless.

              To elaborate, you are not the brain. You are the observer, the thing which exists as a byproduct of the brain’s processes, perhaps even a process yourself within. There’s also plenty of times when you will lose time other than sleep, like concussions, getting blackout drunk, panic attacks, and after those times you have no memory of making decisions or acting in your own accord, but you were. You, the observer, were absent while the brain kept working. So where were you?

              You act as though you’re sure you are still the same observer as the one who went to bed. That is completely unsubstantiated. You may have just been born into your body when you awoke today, and will only have until your body falls back asleep again before you cease to exist, replaced by another process that thinks itself is you, another observer.

              And if ‘you’ one day woke up in a digital world, like our own, it’s you’d be none the wiser, because your self is simply a collection of processes and memories. It’s arbitrary. It’s all dust. There’s not some special ‘continuity’ that keeps you alive somehow.

          • Mossy Feathers (She/They)@pawb.social
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            3 months ago

            Probably. If you’ve ever been under anesthesia then you’ve probably noticed the difference between sleeping under anesthesia and sleeping under normal conditions. Personally, I normally get the feeling that time has passed when I sleep, I didn’t have that feeling when I had my wisdom teeth removed; and anesthesia still doesn’t turn your brain all the way off. I’m pretty sure if your brain actually turned off all the way and then turned back on again, then you’d probably feel like you’re a different person.

          • Infernal_pizza@lemmy.world
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            3 months ago

            You wouldn’t notice because you’d be dead. Your clone wouldn’t notice because it would think it was you. Your friends and family wouldn’t notice because they’d think your clone was you.

      • theneverfox@pawb.social
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        3 months ago

        The body. It’s feeding you vast amounts of information every moment, it’s the one making decisions, you’re the AI assistant providing analysis and advice

        If you clone a tree, you get a similar tree. The branches aren’t in the same place. If you clone a human, why would the nerves be laid out the same way? Even if it’s wired up correctly, without a lifetime of cooperation why would your body take your advice?

        Imagine you wake up. Red looks blue. Everything feels numb. The doctor says “everything looks good, why don’t you try to stand up?”. You want to cooperate with the doctor, but you don’t stand up. You could move, but you don’t. Rationalizing your choices, you tell the doctor you don’t feel like it. You feel your toes, you shift to get away from the prodding of your doctor, but you just can’t muster the will to stand

        Imagine you wake up. Your sight is crystal clear, you feel your body like never before. The doctor says “don’t move yet”. With the self control of a child, you rip out the itchy IV to get the tape off of you. The doctor says something in a stem tone, and you’re filled with rage. You pummel the doctor, then are filled with regret and start to cry

        Emerging science suggests this kind of situation could lead to brand new forms of existential horror

          • theneverfox@pawb.social
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            3 months ago

            The m in stem stands for medicine. Maybe your new body doesn’t trust experts, so when doc spoke in an overly educated tone it provoked aggression. Possibly because of overhearing this tone during incubation and while getting the original brain replaced

            Or maybe I made a typo

      • tabular@lemmy.world
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        3 months ago

        Some sleep is conscious (dreaming) but they’re easily forgotten. Perhaps being unconscious still always has a grain of consciousness (but is just forgotten).

        It seems there is a line of reduced experience while sleeping, while copying seems to imply it’s always a clone (a different ego, a different person).

    • metallic_z3r0@infosec.pub
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      3 months ago

      Maintaining continuity of consciousness is the only thing that would make me feel comfortable with converting myself to a machine intelligence.

      • very_well_lost@lemmy.world
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        3 months ago

        I hate to break it to you, but our meat brains don’t even have continuity of consciousness. We become unconscious all the time. The only real constant is the “hardware” our consciousness emerges from, but even that is always changing.

        • Mossy Feathers (She/They)@pawb.social
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          3 months ago

          Except our brains are still functioning. If they didn’t keep functioning, we’d be brain dead. The point is that there’s a common thread that connects every waking moment together.

        • terminhell@lemmy.dbzer0.com
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          3 months ago

          I don’t get the down votes. Did y’all forget about sleep? No one vividly dreams every night all night long. Often it’s the fade to black going to sleep then the sudden awakening.

            • Echo Dot@feddit.uk
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              3 months ago

              How would you know?

              How do you know you’re not a copy of yesterday’s you? If a clone has your memories and you’re not around anymore, then what’s the difference?

              • Maggoty@lemmy.world
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                3 months ago

                Don’t try to get philosophical about this. There is a hard difference between copying a brain and actually transferring consciousness.

                • Echo Dot@feddit.uk
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                  3 months ago

                  Don’t try to get philosophical about this.

                  Er? It’s a philosophical conversation since, you know, brain uploading is not a thing.

                  If you don’t want to engage in philosophy, you’re in the wrong place.

              • realitista@lemm.ee
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                3 months ago

                You’d have to experience death for the clone to continue being the only copy.

                • Echo Dot@feddit.uk
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                  3 months ago

                  Yeah. In the example above the original is dead, and a clone with all of your memories up until the point of death is generated.

                  In that case, there is continuity of concussions, at least as far as anyone can tell, least of all the clone.

            • pixeltree@lemmy.blahaj.zone
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              3 months ago

              Obviously not, but what is the functional difference? If you can’t tell it’s happening, does it actually matter?

                • pixeltree@lemmy.blahaj.zone
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                  3 months ago

                  Sorry, should have been more specific. If you died in your sleep every night and came back to life in the morning, and you couldn’t tell it was happening, would it matter?

                  It’s not a question with a right answer, I just want to hear your thoughts about it

    • MeekerThanBeaker@lemmy.world
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      3 months ago

      I think the only way we know it is us for sure is if we are conscious in both the original and clone at the same time. Like… okay… I know this is me in the new brain, I’ll shut down the other one.

      • Arthur Besse@lemmy.ml
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        3 months ago

        Like… okay… I know this is me in the new brain, I’ll shut down the other one.

        the other one: i’m pretty sure you’ve got it backwards, pal

        • MeekerThanBeaker@lemmy.world
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          3 months ago

          No, no… you misunderstood. We’re just taking a trip to the brain farm up north. You’ll be able to think with the other brains up there. It’ll be fun.

  • Sam_Bass@lemmy.world
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    3 months ago

    they tried that a few years back via a quadraplegics brain transplant to a normal body. he died on the table. not likely to change that with cloning

    • Echo Dot@feddit.uk
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      3 months ago

      I’ve just looked it up and there has never been a full brain transplant, so I don’t know what you’re on about.

      • T156@lemmy.world
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        3 months ago

        They might have confused it for a head transplant?

        Although neither patient was alive at the time of the transplant.

        I don’t know if a full brain transplant would be feasible, or even a good idea. Not only would none of their senses and motor nerves work for weeks while the brain and nerves re-established themselves, but they would be walking around in a dead person’s face, body and speaking with their voice. That seems genuinely horrific.

      • Sam_Bass@lemmy.world
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        3 months ago

        go look at images of old telephone wiring like when POTS was still the main method.multiply those rats nests of wires by a billion and shrink that them down to the molecular size and you might see the issue

        • Excrubulent@slrpnk.net
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          3 months ago

          I cut a big nerve in my thumb years ago, and apparently plastic surgeons fix that sort of thing.

          They reattached the nerve bundles, but I was told the sheathes could be realigned, but the nerves would have to grow back from the point of the cut all the way to the skin.

          At first one half of my thumb was entirely numb, and over the course of well over a decade I’d get pins & needles as bunches of nerves would finish regrowing, except attached to random channels in the nerve bundle, so my brain had to completely remap all those signals to what they actually meant. Also extreme nerve pain near the cut whenever it was bumped, I assume because many nerves just didn’t grow successfully and remained near that site.

          It felt super weird because hot, cold, pain & touch were all mixed up, but eventually my brain sorted them out. It still feels a little weird, especially near my nail, but I haven’t had a pins & needles experience for a few years.

          The problem with doing that with a neck is that it would take wayyy longer and the chances of the patient dying from complications due to no brain signals working right… yeah I don’t see medical science fixing this unless we can regrow nerves in a much shorter span of time.

          • threelonmusketeers@sh.itjust.works
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            3 months ago

            At first one half of my thumb was entirely numb, and over the course of well over a decade I’d get pins & needles as bunches of nerves would finish regrowing, except attached to random channels in the nerve bundle, so my brain had to completely remap all those signals to what they actually meant.

            It felt super weird because hot, cold, pain & touch were all mixed up, but eventually my brain sorted them out.

            Wow, that’s fascinating. Thanks for sharing your story.

            • Excrubulent@slrpnk.net
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              3 months ago

              Thanks! As far as I know I’m not describing anything too unusual with the mixed-up signals, I think pins & needles is essentially that, just a bunch of nerves randomly firing, so you probably do know what it’s like in little doses.

              I’ve been paying attention to it since I wrote that, and it definitely is still slightly more numb on the affected side, I think I was right that not all the nerves regrew completely.

  • sumguyonline@lemmy.world
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    3 months ago

    There’s a trick most of the population can do to “youth up”. Rewind decades of biological age for your entire body. The answer is out there. Start with the jungle people that even in old age have hearts like 20yr olds.

  • SkyNTP@lemmy.ml
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    3 months ago

    We don’t need immortal billionaires sucking up everyone’s oxygen.

    • Valmond@lemmy.world
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      3 months ago

      Well the “not having extreme longevity” doesn’t seem to function, they are here anyways.

    • toynbee@lemmy.world
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      3 months ago

      If you haven’t, you should watch and/or read Altered Carbon.

      If you choose to watch, it is my opinion that it’s primarily the first season that’s worth watching.

      • Fedizen@lemmy.world
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        3 months ago

        I doubt it. They will just dump shit further away. If their solution default is to make things “somebody else’s problem” there’s no reason to believe they will stop thinking that way.

        • roscoe@lemmy.dbzer0.com
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          3 months ago

          That might be their outlook on “local” pollution for a while, but you don’t think going from 20 years left to centuries to live might affect their opinions on global climate change?

          • naught101@lemmy.world
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            3 months ago

            Not really. Many of them are already heavily invested in life extension tech (not that I think it will work, but it means they’re optimistic). I think their general worldview is that technology will fix it, at least for them.

      • DeanFogg@lemm.ee
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        3 months ago

        They can live forever but have to trade their fortune for it permanently

    • Leate_Wonceslace@lemmy.dbzer0.com
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      3 months ago

      I’m a transhumanist, and I’ve never heard of Picard in the context of something you watch, and what’s being spoken of in the article is something that’s been part of our wider Philosophy for longer than I have.