It pressures the system in those cities or states, which is actual pressure to the system, just not direct pressure on the federal government. History shows you can mount pressure through local and state changes until it gets overwhelming support on a federal level.
You can make the argument there might be more effective or quicker solutions, but this is unquestionably one path toward it.
Mules are maybe the most useful freak of nature (sorta) for humans. They’re still used surprisingly widely - even the US military still keeps them on hand, for similar cases to this one: the terrain is so fucked that ground vehicles are going to have a hard time getting to certain areas.