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Very interesting research!
SUMMARY
Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited. In this study, we demonstrate that NIC increases the abundance and proliferative activity of intestinal stem cells (ISCs) in vivo and ex vivo. Moreover, NIC induces Yes-associated protein (YAP)/Transcriptional coactivator with PDZ-binding motif (TAZ) and Notch signaling in ISCs via α7-nicotinic acetylcholine receptor (nAchR) and protein kinase C (PKC) activation; this effect was not detected in Paneth cells. The inhibition of Notch signaling by dibenzazepine (DBZ) nullified the effects of NIC on ISCs. NIC enhances in vivo tumor formation from ISCs after loss of the tumor suppressor gene Apc, DBZ inhibited NIC-induced tumor growth. Hence, this study identifies a NIC-triggered pathway regulating the stemness and tumorigenicity of ISCs and suggests the use of DBZ as a potential therapeutic strategy for treating intestinal tumors.
No way shock pikachu face
Isn’t it easier to assume that nicotine is a risk factor for every cancer until proven otherwise?
In the book “The Second Brain”: the nervous-system of the gut,
it was identified that nicotene & glutamine-supplementation both destroyed the nervous-system of the gut.
( natural diet never includes pure powder of a single amino-acid, hence the glutamine-induced problem )
What was that book’s author…
Here it is:
https://www.amazon.com/Second-Brain-Groundbreaking-Understanding-Disorders/dp/0060930721/
Much different-looking than the one I had, back in the day.
Dr. Gershon.
Anyways, he was wrong about the nervous-system of the gut being the 2nd brain:
Gut/worm brain it is the 1st.
Brainstem/reptilian brain being the 2nd,
Limbic-system/herd-beast brain being the 3rd,
Cortex/human brain being the 4th.
( the ushniisha, aka the CrownProtrusion of realizers & Buddhas, is the 5th, but Western medicine contempts/disallows it.
When I asked a Western doctor about mine, growing-in, they felt it with their hand, & then told me they wouldn’t waste any money doing tests, because “That Can’t Happen!”, right in my face.
“evidence-based” my arse, when you contempt evidence you just physcially-encountered.
Here you can see a dumbed-down symbolic representation of the CrownProtrusion/ushniisha on Buddha statues, the lump on his head.
https://duckduckgo.com/?q=buddha+head&t=fpas&iax=images&ia=images
it isn’t quite that symmetrical, however:
from the side, it may well look like that, but from the front, it is much narrower, so it grows-in more like a ridge/crest, expanding one’s cranium upwards )
Anyways, we’ve 4 brains, by default, & the 5th is produced through gene-activation, through the inner-light meditation, if you want yours growing-in. ( theta-brainwave, in the edge of sleep, dwelling-in & becoming the subtle boundless-luminance of the inner-light.
Keep doing it for 7+ years, every night, and you should feel the ushniisha beginning growing )
Anyways, please keep off nicotene & glutamine-supplementation, both, for your gut’s health!
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