You google the game to see if smarter people have done the investigating.
If not, you just parse logs and errors best you can and try determine what needs enabling.
Generally though, enabling “everything” doesn’t come with any direct drawbacks. This is basically what bottles will do when you tell it you want to run a game, which will then allow most games to work fine.
I would just run external games through steam with proton if you have those kinds of issues.
You don’t even have to do that.
Wine managers like Bottles make it extremely easy to slap on whatever fixes and wine variants you might need.
How do you know what fixes/Wine variants you need?
You google the game to see if smarter people have done the investigating.
If not, you just parse logs and errors best you can and try determine what needs enabling.
Generally though, enabling “everything” doesn’t come with any direct drawbacks. This is basically what bottles will do when you tell it you want to run a game, which will then allow most games to work fine.