I’ve been running Fedora with KDE on my Razer Blade 15 (2020 Advanced). Without knowing your specific hardware model I think you can run any reasonably popular distro and game happily.

Not equally myself, but you get used to doing things with the non-dominant hand surprisingly fast. Started using lefty mouse due to arm pain and maybe a week or two gets you to non-awkward basic usage.

For music production check out Ubuntu Studio. Any distro can run music production stuff but Ubuntu Studio has all the required bits ready to go.

For DAW I transitioned into Reaper which runs natively on Linux. VST support with wine and yabridge works generally fine. For Native Instruments you need to use a legacy installer. I bet there are still problems with some vendor authorizations. You should just test it out to see if your favorite VSTs are supported.