The industry standard is HPLC (high performance liquid chromatography). Those things go for tens of thousands of dollars up front, plus maintenance and consumables.

If there was a less costly way of doing it, you bet companies would have settled on that by now.

make the best decisions they can

I would recommend an HPLC and a competent analytical chemist to gather data and decide whether or not a batch is safe to consume.

This has been posted to a bunch of different communities, and I’m gonna be a stick in the mud each time.

I’m a process chemist. I do this for a living. I’ve made kilo-scale batches of pharmaceuticals at work that have gone through the regulatory process and made it into people. I went to school for ten years to do this.

This is a colossally dangerous thing.

Every time you run a chemical synthesis, you generate impurities. Slightly different temperatures, concentrations, reagent quality, and a million other things will vary the identities and concentrations of those impurities in your product.

The nature of biochemistry is that most compounds, even at very small concentrations, can have effects. Usually bad ones. So drugs have tight specs on how much of each potential impurity can be present. Usually it’s in the 0.1% range, but sometimes a lot lower.

Detection of impurities at that level cannot be done with ‘hacker’ gear in your garage. So if you do this, you’re going to be taking unknown quantities of unknown impurities.

There are trade-offs. If you’re definitely gonna die without the medicine, then the worst that can happen is you die faster, or more painfully. If it’s medicine to maintain quality of life, then you might die fast and painfully.

I’m not saying the current system is good at all. Medicine is too expensive. It shouldn’t be limited by right wing nutjobs. Those things are true. Those things require a solution.

This is not a good solution.

No. Never. It takes whole teams of people to get it right. (Even then, they sometimes get it wrong.)

That’s a false dichotomy if I’ve ever heard one, dude.

There is exactly one easiest option: be like the rest of the civilized world and ban consumer marketing of medicine. HUGE amounts of the prices of drugs are just down to TV ads. “Ask your doctor about…” is horse shit, let your doctor decide what prescription drugs you need. And fire the cocaine-riddled, law-breaking marketing departments that soak up so much money.

“Our recipes are consistent, like a good espresso maker.”

“Okay cool, how do you know that?”

“So many questions! We’re hackers! We are very smart.”

That’s the thing. They have no way of even knowing if they messed up! I’m not even sure the way they could be messing up is a thing they know they should be worried about.

I’m not disputing the reasoning behind why this is important. But “it is important” does not imply that their solution is the right one.

People make illicit drugs chock full of impurities all the time too, and it fucks people up.

There are standards for purity on pharmaceuticals. Impurities have to be ridiculously low. Lower than you can measure in your garage.

These dudes either don’t know you need to even measure purity or have decided that it’s inconvenient and are ignoring it.

I’m a process chemist. I do this sort of thing for a living.

These guys don’t even know why what they’re suggesting is so dangerous. Do not do any of this.

I sort of feel bad about raining on the parade of the person distilling isopropanol in his garage earlier, but it really is dangerous.

But most of us chemists also need to be reminded of it. To the point that someone had to write a paper whose entire point is “don’t distill isopropanol”.

Please, don’t do this thing.

The issue with isopropanol peroxide formation is that exposing it to air – even when just using it, like when you’re cleaning parts – starts the process. The air in the head space of your containers is also enough to form them over time. You don’t necessarily need to see solids in the containers for it to be dangerous, since they’ll crystallize out as you concentrate the solution during distillation.

It’s also a numbers game. It probably won’t explode the first time you do it. But there’s a chance each time. Do it enough, and you’ll have an incident.

There are chemical reductants that can clear peroxides. For industrial scale isopropanol distillation, I’m not sure what they use. It may be that they just never distill down to the point that peroxides concentrate to a dangerous level.

I love EnF. But I assure you, organic peroxide formers are scarier.

No no no no no.

I’m a chemist. Organic chemistry PhD, now a process chemist in the industry. I do this for a living. Do not distill isopropanol that’s been exposed to air for any meaningful length of time.

Isopropanol slowly reacts with oxygen in the air to generate peroxides that, when you concentrate them down, EXPLODE. Source. Sorry, not an open access journal. But please take my word for it.

Unless you have a way of confirming the peroxide levels in your isopropanol are near zero, do not concentrate it down by distillation. You’ll blow up your glassware, which will probably expose what you’re distilling to your heat source, which will generate a secondary fireball.

PLEASE do not do this.

got lucky

That is not how I’d characterize 2016 at all. Also, I would like to refer you to argument number two.

1. 2016
2. He currently works for a crypto betting market
3. 2016

Why on earth are we still listening to Nate Silver?

Technical people that move into management usually (but not always) suffer from something I’ve started calling management brain rot. They’re exposed to the spreadsheet warriors and their corporate jargon, and it doesn’t take long for the good ones to give up and the bad ones to thrive in a, let’s call it, “low-information environment.”