Everybody knows Marie Curie was a woman and woman’s contributions to science just don’t exist or even register. Women scientists are literally the devil. /s

Others have answered you question about non-directed nuclear blasts in space already. They don’t work the same way as in atmosphere; lack the blast or the thermal heat, etc. Enter the Casaba-Howitzer, a theoretical nuclear shaped charge that shoots a directed plasma stream at near light speed. This idea came about in the 60s along with nuclear blast propulsion.