Scientists at the Skaggs School of Pharmacy and Pharmaceutical Sciences, part of the University of California San Diego, have discovered thousands of new bile acids. These molecules are used by our gut microbiome to communicate with the rest of the body. “Bile acids are a key component of the lan

This study has used publicly available MS/MS spectra for bile-acid-selective ion patterns to identify thousands of polyamine bile amidates. It highlights the existence of many more bile acid modifications than previously recognized and the value of leveraging public large-scale untargeted metabolomics data to discover metabolites.

https://www.cell.com/cell/fulltext/S0092-8674(24)00185-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867424001855%3Fshowall%3Dtrue (open access)