Genetic factors play a crucial role in the development of gout, with several studies highlighting
its strong hereditary component. Twin studies have demonstrated a strong genetic component
in gout, with heritability estimates reaching 60% for uric acid kidney clearance, 87% for uric
acid-to-creatinine ratios, and 28% to 31% for gout itself.
And also towards the end
While observational studies have often linked alcohol intake with gout,
our MR analysis suggests that this association may be confounded by other factors or may not
represent a direct causal relationship.
Right below that it says
Genetic factors play a crucial role in the development of gout, with several studies highlighting its strong hereditary component. Twin studies have demonstrated a strong genetic component in gout, with heritability estimates reaching 60% for uric acid kidney clearance, 87% for uric acid-to-creatinine ratios, and 28% to 31% for gout itself.
And also towards the end
While observational studies have often linked alcohol intake with gout, our MR analysis suggests that this association may be confounded by other factors or may not represent a direct causal relationship.