I’ve tried it many ways. The most efficient method using a fan is to open the windows in a room on the leeward side of the house, then place a fan a few feet in front of the doorway, blowing air into the room. It’s more efficient because the impelled air will entrain surrounding air moving a greater volume through the doorway and out all the windows in that room. Then open windows in the farthest rooms to get a cross breeze.

Also look into an attic fan. They exhaust hot air from the attic, and it makes a world of difference in keeping your interior cool. Another trick is to mount shade cloth 6 inches away from the sunny walls of your home. It absorbs most of the solar radiation and keeps your walls cooler.