The setup process isn’t really much different from other distros, quite easy. It’s documented here. If it’s still too intimidating for you, you could always do a test run in a virtual machine first.

After the initial installation it’s an even better experience than other distros I have used. It gives you a first time portal, where you can choose additional applications that you would like installed. If you get your application via flatpak then you are all setup. If you need other applications not available in flathub, you will have to do some further reading in the documentation, it’s all explained there.